The role of T cells in the development of Henoch-Schonlein purpura.

نویسندگان

  • Yanlin Li
  • Yiping Zhou
  • Diqing Zhu
  • Yongqing Wang
چکیده

Henoch-Schonlein purpura (HSP) is an IgA-mediated disorder that most commonly occurs in children. Its etiology and pathogenesis remain unknown. In recent years, numerous studies have pointed to a dysfunction of T cells in the pathogenesis of HSP. Here, we will review the epidemiology, clinical and molecular characteristics of HSP, as well as abnormalities of Th cell subsets in this disorder. Finally, we will discuss the key factors that are involved in Th cell differentiation as potential novel targets for the prevention and treatment of HSP.

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عنوان ژورنال:
  • Frontiers in bioscience

دوره 23  شماره 

صفحات  -

تاریخ انتشار 2018